Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells
نویسندگان
چکیده
منابع مشابه
Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency
Nucleostemin (NS) is a nucleolar GTP-binding protein that was first identified in neural stem cells, the functions of which remain poorly understood. Here, we report that NS is required for mouse embryogenesis to reach blastulation, maintenance of embryonic stem cell (ESC) self-renewal, and mammary epithelial cell (MEC) reprogramming to induced pluripotent stem (iPS) cells. Ectopic NS also coop...
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Stem cells harbor significant potential for regenerative medicine as well as basic and clinical translational research. Prior to harnessing their reparative nature for degenerative diseases, concerns regarding their genetic integrity and mutation acquisition need to be addressed. Here we review pluripotent and multipotent stem cell response to DNA damage including differences in DNA repair kine...
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Hematopoietic stem cells (HSCs) have the capacity to self-renew and continuously differentiate into all blood cell lineages throughout life. At each branching point during differentiation, interactions with the environment are key in the generation of daughter cells with distinct fates. Here, we examined the role of the cell adhesion molecule JAM-C, a protein known to mediate cellular polarity ...
متن کاملA Review of the Factors Affecting the Proliferation of Neural Stem and Progenitor Cells
Neural stem cells are undifferentiated cells that are located in limited areas of central nervous system. These cells have proliferation and self-renew ability and can be differentiated into neurons and glial cells. Mature nerve cells do not have proliferative ability; and due to the limited number of nerve stem cells, injuries to the nervous system are not recoverable. The purpose of this revi...
متن کاملNucleostemin as a possible progenitor marker of corneal epithelial cells
PURPOSE Nucleostemin, a nuclear protein involved in the regulation of cell cycle and proliferation, is a candidate marker for various stem cells. We examined the expression of nucleostemin as a marker of differentiation and senescence in corneal epithelial progenitor cells. METHODS Nucleostemin expression in normal mouse corneal epithelium was examined by RT-PCR, as well as in cultured mouse ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1301672110